A labial melanotic macule is a well-defined, oval, brown to black, flat patch on the central third of the lower lip. It is the name for a freckle arising on the lip. It is also sometimes called a labial lentigo and when multiple lesions are present, mucosal melanosis. What are the clinical features of labial melanotic freckle The histopathology of labial melanotic macules (appearing on the lips or oral mucosa) and vulvar and penile melanotic macules are similar to cutaneous lentigo simplex, however acanthosis is less prominent . Their occurrence, usually as new pigmented lesions in adult life, can cause concern because they can mimic early melanoma Mucosal melanotic macules (J Am Acad Dermatol 2000;42:640, J Am Acad Dermatol 2014;70:e81) Clinical presentation: Dark asymmetrical macules. Histologic features: Hyperpigmentation of basal keratinocytes Melanocyte density is usually normal or very mildly increased No nested or confluent proliferation of melanocytes. Normal vulvar pigmentatio
A clinical and histologic study of eighty oral melanotic lesions which do not readily fit into recognized categories of melanotic lesions was conducted. These lesions tend to occur in the fifth decade of life and are most frequently seen on the gingiva, with the buccal mucosa and palate the next most frequent sites While histology is nonspecific, labial melanotic macules generally have increased melanin in melanocytes, basal layer keratinocytes, and melanophages in the dermal papillae. A mild degree of acanthosis without elongation of rete ridges may be present. Nuclear atypia is absent. Melanocyte count is normal (Figure 2, Figure 3) Melanotic macules are well-demarcated, fl at, pigmented lesions caused by a deposit of abundant melanin in the basal layer of the epidermis, accompanied by a slight or undetectable increase in the number of melanocytes
Melanotic macule. Blue nevus. Malignant melanoma - classically hard palate. Melanotic macule General. Benign. Clinically apparent lesion. Gross. Flat pigmented lesion less than 10 mm in size . Usually solitary. Image: Melanotic macule - labia (tufts.edu). Microscopic Melanotic macules may occur as a part of syndromes with multisystem anomalies as Peutz-Jeghers syndrome, Carney complex, LEOPARD syndrome, LAMB syndrome; NAME syndrome or Ruvalcaba-Myhresyndrome. The diagnosis must be confirmed by histophato logical study H&E stain. (WC) Synonyms. simple lentigo. LM. melanocytes in epidermis only - hyperpigmentation; no melanocytic nests; +/-mild/moderate elongation of the rete ridges. LM DDx. solar lentigo, ephelis (freckle), melanotic macule, lentiginous nevus, early seborrheic keratosis. Site Background: Genital melanotic macules are poorly recognized lesions, which appear as isolated discrete macules. Their occurrence, usually as new pigmented lesions in adult life, can cause concern because they can mimic early melanoma. Objective: Our purpose was to define the clinical, histologic, immunohistochemical, and electronmicroscopic features of genital melanotic macules The labial melanotic macule and melanoacanthoma demonstrate histologic features strikingly different from those of melanoma. Although intraepithelial dendritic melanocytes are seen in melanoacanthoma, they are mostly present in the lower portions of the epithelium, and there is no full-thickness haphazard dispersion of atypical single and.
Progressive macular hypomelanosis is usually diagnosed by clinical suspicion and supported by the presence of fluorescence on Wood light examination. The hair follicles fluoresce with a red glow, indicating they are colonised by P. acnes. Dermoscopy shows poorly-defined white macules with faint reticular pigmentation In this review, we discuss and provide a summary of important clinical and histopathological concepts of pigmented lesions of the nail unit with special focus on longitudinal melanonychia, melanotic macule, melanocytic nevus, subungual melanoma, along with discussion of some nonmelanocytic lesions Melanotic macules (mucosal melanosis) Melanotic macule is the most common pigmented lesion located in the oral cavity. Lesions located on the lip are termed lip melanotic macule, whereas the those located intra-orally are termed oral melanotic macule. Melanotic macules are benign lesions and have a tendency to spontaneous regression Lentigo maligna clinically presents as a pigmented, asymmetric macule that originates on the head and neck and spreads slowly. The preferred method for diagnosing lentigo maligna is excisional biopsy. Histology shows proliferation of atypical melanocytes at the epidermal-dermal junction in small nests or single cells
Conclusions: This study documents a case of primary oral melanoma arising from an apparent oral melanotic macule and suggests that even histologically benign-appearing oral melanotic lesions should perhaps be viewed with caution if increased numbers of melanocytes (melanocytic hyperplasia or clear cell activity) are present A mucosal melanocytic macule is a well-defined, oval, brown to black, flat patch, usually found on the lip (a labial melanocytic macule). Lesions can also be found in the mouth (oral melanotic macule), on the vulva (vulval labial melanotic macule; vulval melanosis) or on the penis (penile melanotic macule) Diagnosis is often delayed because it presents with minimal nail changes and mimics a number of benign nail conditions. We report a 43-year-old Chinese man who presented with a three-year history of an indolent melanotic macule of the fingernail. Histology from a punch biopsy revealed a well-differentiated squamous cell carcinoma
These pigmented lesions occur on the skin, and in and around the oral cavity. Those occurring on mucosal surfaces demonstrate the histologic changes of labial melanotic macules [43, 44]. Prominent palmoplantar pigmentation with lentigo simplex-like histology on acral skin is also described in these patients [45, 46] . oral melanotic macule-do you treat?-what is the preferred tx-malignant potential?-can look similar to what •don't need to treat except for esthetics •excisional biopsy (remove the whole thing) is the preferred treatment •no malignant potentia
Start studying Oral Pathology - photographs/histology (good). Learn vocabulary, terms, and more with flashcards, games, and other study tools Melanotic macule • Differential diagnosis: 1) Nevus 2) Amalgam tattoo 3) Peutz-Jeghers syndrome - multiple macules in periorificial, oral, and cutaneous distribution - benign intestinal polyps 4) Melanoma Nevus Amalgam tattoo Peutz-Jeghers Melanoma - nodular, ulcerated Melanotic macule • Histology: - increase of melanin in basal laye
melanotic macules can appear on the gingiva, buccal mucosa, palate, and tongue; Labial melanotic macules usually occur on the vermilion of the lower lip. Lesions for both are usually solitary, symmetric, and asymptomatic. Vulvar and penile lentigo are benign lesions similar to labial melanotic macules. In men, the most common sites are the glan Melanotic Macules of Oral Mucosa are observed on the lips, in the mouth, on the tongue, etc. It is a commonly observed skin condition that is seen in many children and adults. The presence of numerous melanotic macules on the body may be associated with a variety of syndromes including Carney complex, Peutz-Jeghers syndrome, and LEOPARD syndrome Skin and tumor tissue samples were examined by routine histology, immunohistochemistry, and in one case also by electron microscopy. Results: Two patients developed diffuse melanotic macules and papules associated with visceral adenocarcinoma. One patient was a 64-year-old man with advanced carcinoma of the distal esophagus
ABSTRACT: Oral nevi, melanotic macules on the lip, atypical amalgam tattoos, melanoacanthomas, and lesions caused by embedded foreign bodies or by perforating injuries of the oral mucosa all require biopsy, since they can resemble melanoma. An important clue in diagnosing melanoma is its marked tendency to ulcerate in the oral cavity. The amelanotic form may be mistaken for a pyogenic. Labial Melanotic Macule. Brown macules on the lower lip are relatively common, especially in young adult women. Histologically, they resemble freckles and not lentigo, but unlike freckles, they do not darken with sun exposure. They are benign. Cryotherapy or laser surgery is used for patients who request treatment Oral malignant melanoma is largely a disease of those older than 40 years, and it is rare in patients younger than 20 years. The average patient age at diagnosis is 56 years. Oral malignant melanoma is commonly diagnosed in men aged 51-60 years, whereas it is commonly diagnosed in females aged 61-70 years • A series of 41 cases of melanotic lesions of the lip from 1980 to 1984 are reported. These lesions occur preponderantly in young white women on the lower lip. The term labial melanotic macule is suggested for these lesions.(Arch Dermatol 1987;123:1029-1031
Dermoscopic findings in melanotic macules and melanomas of the lip. eFigure 1. In vivo confocal images from normal lower lip showing the draped pattern in two patients. eFigure 2. Patient with a recurrent in situ melanoma on her lower lip. eFigure 3. Melanotic macule from the vermillion and part of the inner mucosae in a patient with an Asiatic. Oral melanotic macules are found primarily in adults over 40 years of age. Some authors report a slight female predilection, whereas others describe both sexes being affected equally. The most common sites are the vermilion border, followed by the gingiva, the buccal mucosa and the palate . The presence of numerous melanotic macules on the body may be associated with a variety of syndromes including Carney complex, Peutz-Jeghers syndrome, and LEOPARD syndrome
Eruptive melanotic macules and papules associated with adenocarcinoma Eruptive melanotic macules and papules associated with adenocarcinoma Busam, Klaus J.; Sachs, Dana L.; Coit, Daniel G.; Halpern, Allan; Hwu, Wen‐Jen 2003-01-01 00:00:00 A wide variety of cutaneous manifestations may be associated with malignancies, such as metastatic tumor deposits to the skin, syndromes produced by tumor. In melanin‐laden cells observed in melanotic macules, many melanosome complexes with hydrolytic enzyme activity and a small number of single melanosomes were recognized. We assumed that some or many of the melanin‐laden, melanophage‐like cells in the upper dermis of a regressing malignant melanoma might be effete melanoma cells
Questions: 1. Information. Presented by William Westra, M.D. and prepared by Rui Zheng, M.D., Ph.D. Case 3: 40 year-old man with a pigmented macule involving gingival mucosa. You have already completed the quiz before. Hence you can not start it again RESULTS: Review of blocks and slides of the patient's lesions suggest that the onset of melanocytic hyperplasia (increased clear cell activity) heralded the transformation of the melanotic macule into melanoma. The histology of the first biopsies was totally benign, but retrospectively, the clinical appearance was not typical and was somewhat. Laugier-Hunziker syndrome (LHS) is an acquired melanosis of lips and/or oral mucosa, in half the cases associated with melanonychia striata and, rarely, with hyperpigmentation of other mucocutaneous districts Study Oral Mucosa: Pigmented Lesion flashcards from Sophie L Polowyj's class online, or in Brainscape's iPhone or Android app. Learn faster with spaced repetition Histology of the described cases of lingual melanotic macule reveals increased melanin in the basal cell layer, some pigment-laden macrophages in the dermis, normal number of melanocytes with no or a slight increase of melanin in their interior and variable degrees of hyperkeratosis. 2 There are no nests of melanocytes, atypia, or alterations.
Histology: The number of melanocytes within the epidermis is decreased or there are no melanocytes at all. Variable lymphocytic infiltration, usually mild and often none. Melanotic macule of the lip, HE 40x (4052) Melanocytic macule of the lip, another case: Melanotic macule of the lip, HE 40x (2300) Genital lentigo 1. J N J Dent Assoc. 2003 Fall;74(4):24, 40. Oral pathology quiz #41. Case number 2. Melanotic macule. Litwin BJ. PMID: 14730776 [PubMed - indexed for MEDLINE
† Characteristic melanotic macules, or † One intestinal polyp with PJS-type histology*, or † STK11 mutation *PJS type histology defined as smooth muscle arborization. Figure 1 Physical findings in the patient. A) Multiple melanotic macules on the fingertips characteristic or Peutz-Jeghers syndrome, B) Melanotic macule on the right cheek BACKGROUND: The labial melanotic macule (LMM) is a recently described pigmentary anomaly that may simulate malignant melanoma. OBJECTIVE: Our purpose was to define the LMM clinically, histologically, and immunohistochemically in a large group of patients. METHODS: We describe the clinical features of 36 LMMs in 29 patients (aged from 4 to 79. year history of an indolent melanotic macule of the fingernail. Histology from a punch biopsy revealed a well -differentiated squamous cell carcinoma. Wide local excision with full thickness skin grafting was performed. Physicians should have a high index of clinical suspicion as early nail biopsy and promp 1. Tex Dent J. 2003 May;120(5):446, 453. Oral and maxillofacial pathology case of the month. Melanotic macule. Wright JM(1). Author information: (1)Department of Diagnostic Sciences. PMID The histology of these atypical vulvar nevi can be striking at low power, often with a large nodular and cellular lesion, raising concern for a nodular melanoma . The theques, or nests, have marked variability in size and shape, including large irregular and fusiform forms ( Fig. 2B )
black solar lentigo (Reticulated melanotic macule) is not a solar lentigo. Dermatopath Pract Concept 1995; 1:225-28. 5. Kaddu S, Soyer HP, Wolf IH, Rieger E, Kerl H. Retikulare Lentigo. Hautarzt 1997;48(3):181-5. 6. Wheat CM, WesleyNO, Jackson BA. Recognition of skin cancer and sun protective behaviours in skin of color. J Drugs Dermatol2013. Chapter 25 Melanocytic nevi Bostjan Luzur, Boris C. Bastian, Eduardo Calonje Ephelide 1150 Lentigo simplex 1151 Labial melanotic macule and labial lentigo 1152 Laugier-Hunziker syndrome 1152 Oral melanoacanthoma 1152 Cutaneous melanoacanthoma 1152 Peutz-Jeghers syndrome 1152 Genital lentiginosis 1152 Acral lentigo 1152 Multiple lentigines syndrome 1153 Carney's complex 1153 Centrofacial. Genital Melanotic Macules. Melanotic macules are dark spots that may be observed on the skin, mucus membranes of the mouth, genitalia, and in the nails. Genital Melanotic Macules are observed on the male or female genitalia. In males, the penis is mostly involved; while in females, the vulva is the chief site of these macules Smoker melanosis. It is brown-black homogenous, sometimes with a honeycomb pattern, but nor having a pigmented network pattern.; Mucosal nevi. They have to be differentiate from mucosal macule and sometimes this is difficult.Dermoscopically they display pigmented network (reticular pattern) and dotted-globular pattern.Few colors and the lack of structureless areas Labial melanotic macule after application of topical tacrolimus: two case reports. Zattra E, Albertin C, Belloni Fortina A. Acta Derm Venereol, 90(5):527, 01 Sep 2010 Cited by: 4 articles | PMID: 2081463
Benign melanotic macules can be considered as the mucosal counterpart of lentigos. They present clinically as flat, smooth-bordered, well-defined pigmented lesions. Many variants can be included in this category including oral (labial) melanotic macule, genital melanotic macule, melanosis of the areola, melanosis of acral sites, and melanotic. Transient neonatal pustular melanosis (TNPM) is a harmless skin condition of newborns. The lesions of TNPM are present from birth. They begin as 2-3 mm vesiculopustules (blisters) that are not surrounded by any erythema (redness). These blisters easily rupture, leaving pigmented macules (spots) with a tell-tale collarette of scale histology and these two types tend to show differences clinically .They arejunctional nevi and compound nevi.Both are tend to be appear as brown in colour and may be flat macules or nodular ,sharply defined borders and asymptomatic and most common sites are palate and gingiva (4)(2). Melanotic Macule
Reflectance confocal microscopy features of labial melanotic macule: Report of three cases. Porto AC(1), Fraga-Braghiroli N(2), Blumetti TP(1), Petaccia de Macedo M(1), Rabinovitz H(2), Scope A(3), Tavoloni Braga JC(1). Author information: (1)Cutaneous Oncology Department, AC Camargo Cancer Center, Sao Paulo Melanotic macules are dark spots that may be observed on the skin, mucus membranes of the mouth, genitalia, and in the nails. Melanotic macules are benign and no malignant transformation to a melanoma has been recorded; A macule indicates the presence of a flat, distinct, discolored area of skin less than 1 cm wide Melanotic Macules are dark spots that may be observed on the skin, mucus membranes of the mouth, genitalia, and in the nails. Melanotic Macules are benign and no malignant transformation to a melanoma has been recorded. A macule indicates the presence of a flat, distinct, discolored area of skin less than 1 cm wide
Riehl melanosis typically presents as patchy to diffuse pigmentation, often with a slightly scaly skin surface and satellite pigmented follicular-based macules. The reticular pattern is often observed at the center of the pigmented areas. Some patients complain of erythema, edema, and pruritus preceding the occurrence of the pigmentation macules, intestinal hamartomatous polyposis and an increased risk of cancer in many organs, including the small intestine, colon, stomach, pancreas, breast and genital tract.6 The melanotic spots of Peutz-Jeghers syndrome are characteristically small and multiple, and are very obvious around the lips. Pigmented spots also occur inside th
The Histology Guide Skin Melanotic Macule A And C Pump Probe Images And D Frontiers Germinal Center Alloantibody Responses Mediate Solved Label The Photomicrograph Of Thick Skin Stratum C Blue Histology Integumentary System Induction Of Dfosb In Reward Related Brain Structures After Full Text Use Of Transethosomes For Enhancing The Transdermal. Labial Melanotic Macule. Brown macules on the lower lip are relatively common, especially in young adult women ( Fig. 22.30). Histologically, they resemble freckles and not lentigo, but unlike freckles, they do not darken with sun exposure. They are benign. Cryotherapy or laser surgery is used for patients who request treatment diagnosis and assessment, made from tissue changes characteristic of disease of the oral cavity, jaws and salivary glands. This is a clinical specialty undertaken by laboratory-based personnel. The practice of Oral Pathology includes research and diagnosis of diseases using clinical, radiographic, microscopic, biochemical, or other examinations melanotic: [ mel″ah-not´ik ] characterized by the presence of melanin; pertaining to melanosis Another entity is single focus pigmentation, including melanotic macule, amalgam tattoo, melanocytic nevus, melanocarcinoma, and melanoma [1, 7, 13, 19, 20]. In a study by Fernandez et al. of 155 patients with pigmented mucosal lesions, incisional biopsies determined that 65.2 percent were benign melanocytic nevus [ 20 ]
Melanocytic nevi. Becker's Nevus. Labial Melanotic Macule. Mole Blue Nevus. Mole Recurrent Previously Excised Nevi. Mole Spitz Nevus. Moles Birthmark Congenital Nevi. Moles Compound Nevi. Moles Halo Nevi The pathogenesis of vulvar melanosis is unknown. Clinically, vulvar melanosis presents as a single or more commonly multiple, asymmetric macules or patches, with tan-to-brown color, irregular borders, and variable size. In most cases, it develops on the labia minora, but it can also occur on the labia majora, vaginal introitus and perineum [2,4.
Labial melanotic macule is a well-defined, oval, brown to black, flat patch on the central third of the lower lip. Labial melanotic macule is the name for a freckle arising on the lip and is also sometimes called a labial lentigo of mucosal melanosis or oral melanotic macule A blue‐black macule of recent onset (tumoral melanosis) A blue‐black macule of recent onset (tumoral melanosis) Kossard, Steven 1996-11-01 00:00:00 Steven Kossard Skin and Cancer Foundation, Darlinghurst, New South Wales, Australia SUMMARY The author reports a 75-year-old man who developed a blue-black macule, which on biopsy showed sheets of deeply pigmented melanophages Oral melanotic macules may have more of a predilection toward malignant melanoma than LMM. These macules, noted on gingival, buccal or palatal mucosa, usually present in patients older than age 40. Mucosal melanotic macule • Compared with lentigo simplex can be more irregular and mottled • Oral lesions usually occur in adults > 40 years old on vermillion border > gingiva, buccal mucosa, or palate; genital lesions most common on labia minor